Blar i forfatter "Palica, Katarzyna"

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    • Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose 

      Kondratieva, Alexandra; Palica, Katarzyna; Frøhlich, Christopher; Rolfsnes Hovd, Rebekka; Leiros, Hanna-Kirsti S.; Erdélyi, Máté; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-10)
      Bacterial resistance to the majority of clinically used β-lactam antibiotics is a global health threat and, consequently, the driving force for the development of metallo-β-lactamase (MBL) inhibitors. The rapid evolution of new MBLs calls for new strategies and tools for inhibitor development. In this study, we designed and developed a series of trifluoromethylated captopril analogues as probes for ...

    • Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters 

      Palica, Katarzyna; Vorácová, Manuela; Skagseth, Susann; Andersson Rasmussen, Anna; Allander, Lisa; Hubert, Madlen; Sandegren, Linus; Leiros, Hanna-Kirsti S.; Andersson, Hanna; Erdélyi, Máté (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain-contrary to earlier predictions-a major consideration for the public health of the 21st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance ...